Requirement of DDX3 DEAD Box RNA Helicase for HIV-1 Rev-RRE Export Function

@article{Yedavalli2004RequirementOD,
  title={Requirement of DDX3 DEAD Box RNA Helicase for HIV-1 Rev-RRE Export Function},
  author={Venkat S. R. K. Yedavalli and Christine Neuveut and Ya-hui Chi and Lawrence S. Kleiman and K T Jeang},
  journal={Cell},
  year={2004},
  volume={119},
  pages={381-392}
}
A single transcript in its unspliced and spliced forms directs the synthesis of all HIV-1 proteins. Although nuclear export of intron-containing cellular transcripts is restricted in mammalian cells, HIV-1 has evolved the viral Rev protein to overcome this restriction for viral transcripts. Previously, CRM1 was identified as a cellular cofactor for Rev-dependent export of intron-containing HIV-1 RNA. Here, we present evidence that Rev/CRM1 activity utilizes the ATP-dependent DEAD box RNA… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS