Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells.

@article{Nakajima1997RequirementOC,
  title={Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells.},
  author={Akihito Nakajima and Norihiko Watanabe and Shinichi Yoshino and H. Yagita and Ko Okumura and Miyuki Azuma},
  journal={International immunology},
  year={1997},
  volume={9 5},
  pages={637-44}
}
The interaction between CD28 and its ligands, CD80 and CD86, is crucial for an optimal activation of antigen-specific T cells. However, the requirement of CD80 or CD86 co-stimulation in Th2 cell differentiation and activation is controversial. Freshly isolated murine CD4+ and CD8+ T cells were incubated with P815 transfectants expressing a similar level of either CD80 or CD86 in the presence of anti-CD3 mAb. Both CD80 and CD86 co-stimulated the proliferation of CD4+ and CD8+ T cells at… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

A detailed phenotypic analysis of immune cell populations in the bronchoalveolar lavage fluid of atopic asthmatics after segmental allergen challenge

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology • 2013
View 8 Excerpts
Highly Influenced

Allergic bronchopulmonary aspergillosis in cystic fibrosis--state of the art: Cystic Fibrosis Foundation Consensus Conference.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2003

Lymphocytes in allergic bronchopulmonary aspergillosis.

Frontiers in bioscience : a journal and virtual library • 2003

References

Publications referenced by this paper.
Showing 1-10 of 42 references

B7-1 and B7-2 co-stimulatory molecules Immunol

L. H. Glimcher
8:303. • 1995

CD 28 - T helper 1 and 2 populations is lost after long - term stimulation . B 7 blockade after alloantigenic challenge in vivo inhibits Th 1

P. S. Linsley, L. A. Turka
J . Exp . Med . • 1995

CD28 ligands CD80 (B7-1) and CD86 (B7-2) in SJA/9 and nude mice; potentiation of IgE production

C H.
1995
View 2 Excerpts

10 crossregulation of Th 1 and Th 2 responses

T. R. Mosmann, P. S. Linsley, J. L. Hughes, J. E. Jones
Immunol . • 1994

Similar Papers

Loading similar papers…