Requirement of Bmp8b for the generation of primordial germ cells in the mouse.

  title={Requirement of Bmp8b for the generation of primordial germ cells in the mouse.},
  author={Yan Mei Ying and Xiao Min Liu and Alexander Marble and Kirstie A. Lawson and Guang Quan Zhao},
  journal={Molecular endocrinology},
  volume={14 7},
In the mouse embryo, the generation of primordial germ cells (PGCs) from the epiblast requires a bone morphogenetic protein-4 (BMP4) signal from the adjacent extraembryonic ectoderm. In this study, we report that Bmp8b, a member of the Gbb-60A class of the BMP superfamily, is expressed in the extraembryonic ectoderm in pregastrula and gastrula stage mouse embryos and is required for PGC generation. A mutation in Bmp8b on a mixed genetic background results in the absence of PGCs in 43% null… CONTINUE READING
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