Requirement of B cells for generating CD4+ T cell memory.

  title={Requirement of B cells for generating CD4+ T cell memory.},
  author={Jason K Whitmire and Mary S. Asano and Susan M Kaech and Surojit Sarkar and Lynn G. Hannum and Mark J. Shlomchik and Rafi Ahmed},
  journal={Journal of immunology},
  volume={182 4},
B cells can influence T cell responses by directly presenting Ag or by secreting Ab that binds to Ag to form immunogenic complexes. Conflicting evidence suggests that persisting Ag-Ab complexes propagate long-term T cell memory; yet, other data indicate that memory cells can survive without specific Ag or MHC. In this study, the roles of B cells and Ag-Ab… CONTINUE READING