Requirement for yeast RAD26, a homolog of the human CSB gene, in elongation by RNA polymerase II.

@article{Lee2001RequirementFY,
  title={Requirement for yeast RAD26, a homolog of the human CSB gene, in elongation by RNA polymerase II.},
  author={S K Lee and S L Yu and L. T. Om Prakash and Satya Prakash},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 24},
  pages={8651-6}
}
Mutations in the human CSB gene cause Cockayne syndrome (CS). In addition to increased photosensitivity, CS patients suffer from severe developmental abnormalities, including growth retardation and mental retardation. Whereas a deficiency in the preferential repair of UV lesions from the transcribed strand accounts for the increased photosensitivity of CS patients, the reason for developmental defects in these individuals has remained unclear. Here we provide in vivo evidence for a role of… CONTINUE READING
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