Requirement for thrombin receptor occupancy during platelet secretion under aggregating and non-aggregating conditions.

@article{Koike1987RequirementFT,
  title={Requirement for thrombin receptor occupancy during platelet secretion under aggregating and non-aggregating conditions.},
  author={Kichiko Koike and Holm Holmsen},
  journal={Thrombosis and haemostasis},
  year={1987},
  volume={58 4},
  pages={1053-9}
}
The requirement for receptor occupancy in thrombin-induced secretion in human platelets has been studied. When increasing concentrations of thrombin were added to gel-filtered platelets containing a constant, high concentration of hirudin, dense granule secretion was initiated at lower thrombin concentrations than those required for alpha-granule secretion… CONTINUE READING