Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation.

@article{Namkung2001RequirementFT,
  title={Requirement for the L-type Ca(2+) channel alpha(1D) subunit in postnatal pancreatic beta cell generation.},
  author={Yoon Namkung and N. V. Skrypnyk and Moon Jin Jeong and Tsung-I. Lee and Marjan Holloway Alice Sterling Honig Samuel Gui - Hai Hua Lee and Hung Leung Kim and H Chin and Pann Ghill Suh and Sang Soo Kim and Hyoung Seek Shin},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 7},
  pages={1015-22}
}
Pancreatic beta cells are the source of insulin, which directly lowers blood glucose levels in the body. Our analyses of alpha(1D) gene-knockout (alpha(1D)(-/-)) mice show that the L-type calcium channel, alpha(1D), is required for proper beta cell generation in the postnatal pancreas. Knockout mice were characteristically slightly smaller than their littermates and exhibited hypoinsulinemia and glucose intolerance. However, isolated alpha(1D)(-/-) islets persisted in glucose sensing and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2014
View 2 Excerpts

Ionic mechanisms in pancreatic β cell signaling

Cellular and Molecular Life Sciences • 2014

Similar Papers

Loading similar papers…