Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction.

  title={Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction.},
  author={Deborah E. Isaksen and Heinz Baumann and Patty A. Trobridge and Andrew G. Farr and S. D. Levin and Steven F. Ziegler},
  journal={Journal of immunology},
  volume={163 11},
Thymic stromal lymphopoietin (TSLP) is a newly identified cytokine that uniquely promotes B lymphopoiesis to the B220+/IgM+ immature B cell stage. In addition, TSLP shares many biological properties with the related cytokine IL-7. This can be explained by the finding that the receptor complexes for TSLP and IL-7 both contain the IL-7R alpha-chain; IL-7Ralpha is paired with the common gamma-chain (gammac) in the IL-7 receptor complex and the unique TSLP-R chain in the TSLP receptor complex… CONTINUE READING


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