Requirement for proteolysis in spindle assembly checkpoint silencing.

  title={Requirement for proteolysis in spindle assembly checkpoint silencing.},
  author={Roberta Visconti and Luca Palazzo and Domenico Luca Grieco},
  journal={Cell cycle},
  volume={9 3},
Anaphase initiation requires ubiquitin-dependent proteolysis of crucial substrates through activation of the ubiquitin ligase Anaphase promoting Complex/Cyclosome (ApC/C) in association with its coactivator Cdc20. To prevent chromosome segregation errors, effector proteins of a safeguard mechanism called spindle assembly checkpoint (SAC), Mad2 and BubR1, bind Cdc20 and restrain ApC/C(Cdc20) activation until spindle assembly. Coordinated chromosome segregation also requires timely SAC… CONTINUE READING


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