Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis

  title={Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis},
  author={Elizabeth A. Slee and Xin Lu},
  booktitle={Scientific reports},
The p53 tumour suppressor is activated in response to a wide variety of genotoxic stresses, frequently via post-translational modification. Using a knock in mouse model with a Ser312 to Ala mutation, we show here that phosphorylation of p53 on Ser312 helps to prevent tumour induction by the alkylating agent MNU, which predominantly caused T cell lymphomas. This is consistent with our previous observation that p53(312A/A) mice are more susceptible to X-ray induced tumourigenesis. Phosphorylation… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 44 references

analysis of p53 serine 312 phosphorylation in vivo

  • E. A. Slee, Lu, X. In the right place at the right time
  • Cell Cycle 10, 1345–1346
  • 2011

partners in life and death

  • S. Polager, Ginsberg, D. p53, E2f
  • Nat Rev Cancer 9, 738–748
  • 2009

A positive control chemical for p531/2 mouse carcinogenicity studies

  • Morton, D. et al. N-Methyl-N-Nitrosourea MNU
  • Toxicol Pathol 36, 926–931
  • 2008

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