Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis

@inproceedings{Slee2013RequirementFP,
  title={Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis},
  author={Elizabeth A. Slee and Xin Lu},
  booktitle={Scientific reports},
  year={2013}
}
The p53 tumour suppressor is activated in response to a wide variety of genotoxic stresses, frequently via post-translational modification. Using a knock in mouse model with a Ser312 to Ala mutation, we show here that phosphorylation of p53 on Ser312 helps to prevent tumour induction by the alkylating agent MNU, which predominantly caused T cell lymphomas. This is consistent with our previous observation that p53(312A/A) mice are more susceptible to X-ray induced tumourigenesis. Phosphorylation… CONTINUE READING
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