Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation.

@article{Suter1991RequirementFP,
  title={Requirement for phosphorylation and localization of the Bicaudal-D protein in Drosophila oocyte differentiation.},
  author={Bernhard Suter and R. Steward},
  journal={Cell},
  year={1991},
  volume={67 5},
  pages={917-26}
}
In the Drosophila female the product of the germline stem cell, the cystoblast, gives rise to 16 interconnected cystocytes. One of them differentiates into the oocyte, while the 15 others become polyploid nurse cells. Bic-D is required for the differentiation of an oocyte and hence for fertility. Recessive mutations in Bic-D block the oocyte-specific accumulation of its own and other RNAs. Based on its properties and distribution, the Bic-D protein appears to be a component of a cytoskeletal… CONTINUE READING
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