Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion.

@article{Yeh2001RequirementFP,
  title={Requirement for p38 and p44/p42 mitogen-activated protein kinases in RAGE-mediated nuclear factor-kappaB transcriptional activation and cytokine secretion.},
  author={C. H. Yeh and Lydia T Sturgis and J Haidacher and Xiaoning Zhang and Sidney J Sherwood and Robert J. Bjercke and Ondrej Juhasz and Michael T. Crow and Ronald G. Tilton and Larry A. Denner},
  journal={Diabetes},
  year={2001},
  volume={50 6},
  pages={1495-504}
}
Advanced glycation end product (AGE) activation of the signal-transducing receptor for AGE (RAGE) has been linked to a proinflammatory phenotypic change within cells. However, the precise intracellular signaling pathways involved have not been elucidated. We demonstrate here that human serum albumin modified with N(epsilon)-(carboxymethyl)lysine (CML), a major AGE adduct that progressively accumulates with aging, diabetes, and renal failure, induced nuclear factor (NF)-kappaB-driven reporter… CONTINUE READING
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