Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.

@article{Tano2011RequirementFN,
  title={Requirement for non-regulated, constitutive calcium influx in macrophage survival signaling.},
  author={Jean-Yves Tano and Guillermo A. V{\'a}zquez},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={407 2},
  pages={
          432-7
        }
}
The phosphatidylinositol-3-kinase (PI3K)/AKT axis and the Nuclear Factor kappa B (NFκB) pathway play critical roles in macrophage survival. In cells other than macrophages proper operation of those two pathways requires Ca²(+) influx into the cell, but if that is the case in macrophages remains unexplored. In the present work we used THP-1-derived macrophages and a pharmacological approach to examine for the first time the role of constitutive, non-regulated Ca²(+) influx in PI3K/AKT and NFκB… CONTINUE READING

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