Requirement for math5 in the development of retinal ganglion cells.

@article{Wang2001RequirementFM,
  title={Requirement for math5 in the development of retinal ganglion cells.},
  author={Steven W. Wang and Bum Shik Kim and Kan Ding and Hongfang Wang and D Sun and Randy L. Johnson and William H. Klein and Lin Gan},
  journal={Genes & development},
  year={2001},
  volume={15 1},
  pages={24-9}
}
math5 is a murine orthologue of atonal, a bHLH proneural gene essential for the formation of photoreceptors and chordotonal organs in Drosophila. The expression of math5 coincides with the onset of retinal ganglion cell (RGC) differentiation. Targeted deletion of math5 blocks the initial differentiation of 80% of RGCs and results in an increase in differentiated amacrine cells. Furthermore, the absence of math5 abolishes the retinal expression of brn-3b and the formation of virtually all brn-3b… CONTINUE READING
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