Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1.

@article{GarciaRodriguez2000RequirementFI,
  title={Requirement for integration of phorbol 12-myristate 13-acetate and calcium pathways is preserved in the transactivation domain of NFAT1.},
  author={Carmen Garcia-Rodriguez and Anjana Rao},
  journal={European journal of immunology},
  year={2000},
  volume={30 8},
  pages={2432-6}
}
The transcription factor NFAT integrates signals from both calcium- and phorbol ester-stimulated signaling pathways. The calcium signal activates the calmodulin (CaM)-dependent phosphatase calcineurin, which dephosphorylates the regulatory domain of NFAT and promotes its nuclear import, while the phorbol ester signal results in synthesis and activation of Fos and Jun, transcription factors that bind cooperatively with the NFAT DNA-binding domain in the nucleus to mediate the transcription of… CONTINUE READING