Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

@article{Hoeflich2000RequirementFG,
  title={Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation},
  author={Klaus P. Hoeflich and Juan Luo and Elizabeth A. Rubie and Ming-Sound Tsao and O C Jin and James R Woodgett},
  journal={Nature},
  year={2000},
  volume={406},
  pages={86-90}
}
Glycogen synthase kinase-3 (GSK-3)-α and -β are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell proliferation in adult tissues. Insight into the physiological function of GSK-3 has emerged from genetic analysis in Drosophila, Dictyostelium and yeast. Here we show that disruption of the murine GSK-3β gene results in embryonic lethality caused by severe liver degeneration during mid-gestation, a phenotype… CONTINUE READING
91 Citations
50 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 91 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

NF - k B activation by tumour necrosis factor requires the Akt serine - threonine kinase

  • O. N. Ozes
  • Nature
  • 1999

Resistance to endotoxic shock as a consequence of defective NFk B activation in poly ( ADP - ribose ) polymerase - 1 de ® cient mice

  • F. J. Oliver
  • EMBO J .
  • 1999

Similar Papers

Loading similar papers…