Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

  title={Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation},
  author={Klaus P. Hoeflich and Juan Luo and Elizabeth A. Rubie and Ming-Sound Tsao and O C Jin and James R Woodgett},
Glycogen synthase kinase-3 (GSK-3)-α and -β are closely related protein-serine kinases, which act as inhibitory components of Wnt signalling during embryonic development and cell proliferation in adult tissues. Insight into the physiological function of GSK-3 has emerged from genetic analysis in Drosophila, Dictyostelium and yeast. Here we show that disruption of the murine GSK-3β gene results in embryonic lethality caused by severe liver degeneration during mid-gestation, a phenotype… CONTINUE READING
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