Requirement for deoxycytidine kinase in T and B lymphocyte development.

@article{Toy2010RequirementFD,
  title={Requirement for deoxycytidine kinase in T and B lymphocyte development.},
  author={Gerald Toy and Wayne R. Austin and H Liao and Donghui Cheng and Arun S. Singh and Dean Campbell and Tomo-o Ishikawa and Lynn W Lehmann and Nagichettiar Satyamurthy and Michael E. Phelps and Harvey R. Herschman and Johannes G Czernin and Owen N Witte and Caius G Radu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 12},
  pages={5551-6}
}
Deoxycytidine kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. dCK phosphorylates and therefore activates nucleoside analog prodrugs frequently used in cancer, autoimmunity, and viral infections. In contrast to its well established therapeutic relevance, the biological function of dCK remains enigmatic. Highest levels of dCK expression are found in thymus and bone marrow, indicating a possible role in… CONTINUE READING

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