Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis.

  title={Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis.},
  author={Niko F{\"o}ger and Linda K. Rangell and Dimitry M. Danilenko and Andrew Che-On Chan},
  volume={313 5788},
The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1-/- mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for… CONTINUE READING
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