Requirement for coenzyme Q in plasma membrane electron transport.

  title={Requirement for coenzyme Q in plasma membrane electron transport.},
  author={Iris Sun and Edna E. Sun and Frederick L. Crane and Dorothy M. Morr{\'e} and Anders Lindgren and Hans Loew},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 23},
Coenzyme Q is required in the electron transport system of rat hepatocyte and human erythrocyte plasma membranes. Extraction of coenzyme Q from the membrane decreases NADH dehydrogenase and NADH:oxygen oxidoreductase activity. Addition of coenzyme Q to the extracted membrane restores the activity. Partial restoration of activity is also found with alpha-tocopherylquinone, but not with vitamin K1. Analogs of coenzyme Q inhibit NADH dehydrogenase and oxidase activity and the inhibition is… CONTINUE READING


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