Requirement for cholinergic synaptic transmission in the propagation of spontaneous retinal waves.

@article{Feller1996RequirementFC,
  title={Requirement for cholinergic synaptic transmission in the propagation of spontaneous retinal waves.},
  author={Marla B Feller and D P Wellis and David Stellwagen and Frank S. Werblin and Carla J. Shatz},
  journal={Science},
  year={1996},
  volume={272 5265},
  pages={1182-7}
}
Highly correlated neural activity in the form of spontaneous waves of action potentials is present in the developing retina weeks before vision. Optical imaging revealed that these waves consist of spatially restricted domains of activity that form a mosaic pattern over the entire retinal ganglion cell layer. Whole-cell recordings indicate that wave generation requires synaptic activation of neuronal nicotinic acetylcholine receptors on ganglion cells. The only cholinergic cells in these… CONTINUE READING
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