Requirement for cell-to-cell contact for the immunosuppressive activity of human alveolar macrophages.

@article{Rich1991RequirementFC,
  title={Requirement for cell-to-cell contact for the immunosuppressive activity of human alveolar macrophages.},
  author={Elizabeth A. Rich and Colin Cooper and Zahra Toossi and Marty L. Leonard and R M Stucky and Robert Wiblin and Jerrold J. Ellner},
  journal={American journal of respiratory cell and molecular biology},
  year={1991},
  volume={4 3},
  pages={287-94}
}
The ability of alveolar macrophages (AM) obtained by bronchoalveolar lavage of healthy volunteers to suppress T lymphocyte responses to the mitogen phytohemagglutinin (PHA) in vitro was investigated. AM but not monocytes (MN) inhibited responses of peripheral blood mononuclear cells (PBMC) to PHA as measured by incorporation of [3H]thymidine [( 3H]TdR) and interleukin-2 (IL-2) expression. Supernatants of AM generated for various periods and with various concentrations of cells did not, however… CONTINUE READING

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