Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development.

  title={Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development.},
  author={Martin R. Mueller and Yoshiteru Sasaki and Irena Stevanovic and Edward D. Lamperti and Srimoyee Ghosh and Sonia Sharma and Curtis Gelinas and Derrick J Rossi and Matthew E. Pipkin and K. Rajewsky and Patrick G. Hogan and Anjana Rao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 17},
NFAT transcription factors are highly phosphorylated proteins residing in the cytoplasm of resting cells. Upon dephosphorylation by the phosphatase calcineurin, NFAT proteins translocate to the nucleus, where they orchestrate developmental and activation programs in diverse cell types. NFAT is rephosphorylated and inactivated through the concerted action of at least 3 different kinases: CK1, GSK-3, and DYRK. The major docking sites for calcineurin and CK1 are strongly conserved throughout… CONTINUE READING
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Expression analysis of nuclear factor of activated T cells (NFAT) during myeloid differentiation of CD34 cells: Regulation of Fas ligand gene expression in megakaryocytes

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A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT

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