Requirement for anticoagulant heparan sulfate in the fibroblast growth factor receptor complex.

@article{Mckeehan1999RequirementFA,
  title={Requirement for anticoagulant heparan sulfate in the fibroblast growth factor receptor complex.},
  author={Wallace L. Mckeehan and Xiaoyun Wu and Mikio Kan},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 31},
  pages={21511-4}
}
A divalent cation-dependent association between heparin or heparan sulfate and the ectodomain of the fibroblast growth factor (FGF) receptor kinase (FGFR) restricts FGF-independent trans-phosphorylation between self-associated FGFR and determines specificity for and mediates binding of activating FGF. Here we show that only the fraction of commercial heparin or rat liver heparan sulfate which binds to immobilized antithrombin formed an FGF-binding binary complex with the ectodomain of the FGFR… CONTINUE READING