Requirement for a functional Rb-1 gene in murine development.


Human retinoblastomas can occur both as hereditary and as sporadic cases. Knudson's proposal that they result from two mutational events, of which one is present in the germ line in hereditary cases, has been confirmed by more recent molecular analysis, which has shown both events to involve loss or mutational inactivation of the same gene, RB-1 (ref. 2… (More)


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@article{Clarke1992RequirementFA, title={Requirement for a functional Rb-1 gene in murine development.}, author={A. R. Clarke and E R Maandag and Marian A van Roon and N Margreth van der Lugt and Martin A van der Valk and Michele L Hooper and Anne E. Berns and Hans te Riele}, journal={Nature}, year={1992}, volume={359 6393}, pages={328-30} }