Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.

@article{Liberati2004RequirementFA,
  title={Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.},
  author={N. Liberati and K. Fitzgerald and D. Kim and R. Feinbaum and D. Golenbock and F. Ausubel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 17},
  pages={
          6593-8
        }
}
  • N. Liberati, K. Fitzgerald, +3 authors F. Ausubel
  • Published 2004
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • The p38 mitogen-activated protein kinase pathway regulates innate immune responses in evolutionarily diverse species. We have previously shown that the Caenorhabditis elegans p38 mitogen-activated protein kinase, PMK-1, functions in an innate immune response pathway that mediates resistance to a variety of microbial pathogens. Here, we show that tir-1, a gene encoding a highly conserved Toll/IL-1 resistance (TIR) domain protein, is also required for C. elegans resistance to microbial pathogens… CONTINUE READING
    A Role for SKN-1/Nrf in Pathogen Resistance and Immunosenescence in Caenorhabditis elegans
    82

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