Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.

@article{Liberati2004RequirementFA,
  title={Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.},
  author={Nicole T. Liberati and Katherine A. Fitzgerald and Dennis H Kim and Rhonda Feinbaum and Douglas T Golenbock and Frederick M. Ausubel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 17},
  pages={6593-8}
}
The p38 mitogen-activated protein kinase pathway regulates innate immune responses in evolutionarily diverse species. We have previously shown that the Caenorhabditis elegans p38 mitogen-activated protein kinase, PMK-1, functions in an innate immune response pathway that mediates resistance to a variety of microbial pathogens. Here, we show that tir-1, a gene encoding a highly conserved Toll/IL-1 resistance (TIR) domain protein, is also required for C. elegans resistance to microbial pathogens… CONTINUE READING
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Caenorhabditis elegans: A Modern Biological Analysis of an Organism (Academic

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