Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.

@article{Schaeffer1999RequirementFT,
  title={Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.},
  author={Edward Schaeffer and Jayanta Debnath and George S. Yap and D. Neil Mcvicar and Xiaoling C. Liao and Dan R. Littman and Alan Sher and Harold Varmus and Michael J Lenardo and Pamela L Schwartzberg},
  journal={Science},
  year={1999},
  volume={284 5414},
  pages={
          638-41
        }
}
T cell receptor (TCR) signaling requires activation of Zap-70 and Src family tyrosine kinases, but requirements for other tyrosine kinases are less clear. Combined deletion in mice of two Tec kinases, Rlk and Itk, caused marked defects in TCR responses including proliferation, cytokine production, and apoptosis in vitro and adaptive immune responses to Toxoplasma gondii in vivo. Molecular events immediately downstream from the TCR were intact in rlk-/-itk-/- cells, but intermediate events… CONTINUE READING
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