Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

  title={Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells},
  author={Andrew M Intlekofer and Naofumi Takemoto and Charlly Kao and Arnob Banerjee and Felix Schambach and John K. Northrop and Hao Shen and Elaine Wherry and Steven L Reiner},
  journal={The Journal of Experimental Medicine},
  pages={2015 - 2021}
Immunity to intracellular pathogens requires dynamic balance between terminal differentiation of short-lived, cytotoxic effector CD8+ T cells and self-renewal of central-memory CD8+ T cells. We now show that T-bet represses transcription of IL-7Ralpha and drives differentiation of effector and effector-memory CD8+ T cells at the expense of central-memory cells. We also found T-bet to be overexpressed in CD8+ T cells that differentiated in the absence of CD4+ T cell help, a condition that is… CONTINUE READING
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