Requirement for Rho in integrin signalling.

  title={Requirement for Rho in integrin signalling.},
  author={Simon T. Barry and Helen Flinn and Michael J Humphries and David R. Critchley and Anne J Ridley},
  journal={Cell adhesion and communication},
  volume={4 6},
Overnight culture of Swiss 3T3 cells in serum-free medium leads to loss of focal adhesions and associated actin stress fibres, although the cells remain well spread. The small GTP-binding protein Rho is required for the formation of stress fibres and focal adhesions induced by growth factors such as lysophosphatidic acid (LPA) in serum-starved Swiss 3T3 cells, and for the LPA-induced tyrosine phosphorylation of several focal adhesion proteins. Plating of cells on extracellular matrix proteins… CONTINUE READING
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