Requirement for RORgamma in thymocyte survival and lymphoid organ development.

@article{Sun2000RequirementFR,
  title={Requirement for RORgamma in thymocyte survival and lymphoid organ development.},
  author={Zhaoyong Sun and Derya Unutmaz and Y R Zou and Mary Jean Sunshine and Alessandra Pierani and Susan Brenner-Morton and Reina E Mebius and Dan R. Littman},
  journal={Science},
  year={2000},
  volume={288 5475},
  pages={
          2369-73
        }
}
Most developing thymocytes undergo apoptosis because they cannot interact productively with molecules encoded by the major histocompatibility complex. Here, we show that mice lacking the orphan nuclear hormone receptor RORgamma lose thymic expression of the anti-apoptotic factor Bcl-xL. RORgamma thus regulates the survival of CD4+8+ thymocytes and may control the temporal window during which thymocytes can undergo positive selection. RORgamma was also required for development of lymph nodes and… CONTINUE READING

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