Requirement for RORgamma in thymocyte survival and lymphoid organ development.

@article{Sun2000RequirementFR,
  title={Requirement for RORgamma in thymocyte survival and lymphoid organ development.},
  author={Z. Sun and D. Unutmaz and Y. Zou and M. J. Sunshine and A. Pierani and S. Brenner-Morton and R. Mebius and D. Littman},
  journal={Science},
  year={2000},
  volume={288 5475},
  pages={
          2369-73
        }
}
Most developing thymocytes undergo apoptosis because they cannot interact productively with molecules encoded by the major histocompatibility complex. [...] Key Result RORgamma was also required for development of lymph nodes and Peyer's patches, but not splenic follicles. In its absence, there was loss of a population of CD3-CD4+CD45+ cells that normally express RORgamma and that are likely early progenitors of lymphoid organs. Hence, RORgamma has critical functions in T cell repertoire selection and lymphoid…Expand
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