Requirement for Phe36 for DNA binding and mismatch repair by Escherichia coli MutS protein.

@article{Yamamoto2000RequirementFP,
  title={Requirement for Phe36 for DNA binding and mismatch repair by Escherichia coli MutS protein.},
  author={Ayako Yamamoto and Mark J. Schofield and Indranil Biswas and Peggy Hsieh},
  journal={Nucleic acids research},
  year={2000},
  volume={28 18},
  pages={3564-9}
}
The MutS family of DNA repair proteins recognizes base pair mismatches and insertion/deletion mismatches and targets them for repair in a strand-specific manner. Photocrosslinking and mutational studies previously identified a highly conserved Phe residue at the N-terminus of Thermus aquaticus MutS protein that is critical for mismatch recognition in vitro. Here, a mutant Escherichia coli MutS protein harboring a substitution of Ala for the corresponding Phe36 residue is assessed for… CONTINUE READING
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