Requirement for NF-kappaB in osteoclast and B-cell development.

  title={Requirement for NF-kappaB in osteoclast and B-cell development.},
  author={Guido Franzoso and Louise M. Carlson and Luzhou Xing and Ljiljana Poljak and Elizabeth W. Shores and Kevin Brown and Antonio Alessio Leonardi and Tom Tran and Brendan F. Boyce and Ulrich K Siebenlist},
  journal={Genes & development},
  volume={11 24},
NF-kappaB is a family of related, dimeric transcription factors that are readily activated in cells by signals associated with stress or pathogens. These factors are critical to host defense, as demonstrated previously with mice deficient in individual subunits of NF-kappaB. We have generated mice deficient in both the p50 and p52 subunits of NF-kappaB to reveal critical functions that may be shared by these two highly homologous proteins. We now demonstrate that unlike the respective single… CONTINUE READING
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