Requirement for Matrix Metalloproteinase Stromelysin-3 in Cell Migration and Apoptosis during Tissue Remodeling in Xenopus laevis

@article{IshizuyaOka2000RequirementFM,
  title={Requirement for Matrix Metalloproteinase Stromelysin-3 in Cell Migration and Apoptosis during Tissue Remodeling in Xenopus laevis},
  author={Atsuko Ishizuya-Oka and Qing Li and Tosikazu Amano and Sashko Damjanovski and Shuichi Ueda and Yunbo Shi},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={1177 - 1188}
}
The matrix metalloproteinase (MMP) stromelysin-3 (ST3) was originally discovered as a gene whose expression was associated with human breast cancer carcinomas and with apoptosis during organogenesis and tissue remodeling. It has been shown previously, in our studies as well as those by others, that ST3 mRNA is highly upregulated during apoptotic tissue remodeling during Xenopus laevis metamorphosis. Using a function-blocking antibody against the catalytic domain of Xenopus ST3, we demonstrate… CONTINUE READING
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