Requirement for IL-13 independently of IL-4 in experimental asthma.

@article{Grnig1998RequirementFI,
  title={Requirement for IL-13 independently of IL-4 in experimental asthma.},
  author={G Gr{\"u}nig and Mary Warnock and Adil E. Wakil and Rajeev V Venkayya and Frank Brombacher and Donna M. Rennick and Dean Sheppard and Markus Mohrs and Debra D. Donaldson and Richard M Locksley and David B Corry},
  journal={Science},
  year={1998},
  volume={282 5397},
  pages={2261-3}
}
The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective neutralization of IL-13, a cytokine related to IL-4 that also binds to the alpha chain of the IL-4 receptor, ameliorated the asthma phenotype, including airway hyperresponsiveness, eosinophil recruitment, and mucus overproduction. Administration of either IL-13 or IL-4 conferred an asthma-like phenotype to… CONTINUE READING
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