Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates

@article{Xu2017RequirementFE,
  title={Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates},
  author={Y. Xu and Hua Quan and Y. Wang and H. Zhong and J. Sun and J. Xu and N. Jia and Y. Jiang},
  journal={Frontiers in Cellular and Infection Microbiology},
  year={2017},
  volume={7}
}
  • Y. Xu, Hua Quan, +5 authors Y. Jiang
  • Published 2017
  • Medicine, Biology
  • Frontiers in Cellular and Infection Microbiology
  • Candida albicans is one of the most common fungal pathogens. Our previous study demonstrated that concomitant use of berberine (BBR) and fluconazole (FLC) showed a synergistic action against FLC-resistant C. albicans in vitro and BBR had a major antifungal effect in the synergism, while FLC played a role of increasing the intracellular BBR concentration. Since the antifungal activity of BBR alone is very weak (MIC > 128 μg/mL), it was assumed that FLC-resistant C. albicans was naturally… CONTINUE READING

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