Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor

@inproceedings{Su2005RequirementFC,
  title={Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor},
  author={Helen C. Su and Nicolas Bid{\`e}re and Lixin Zheng and Alan Cubre and Keiko Sakai and Janet K. Dale and L Salmena and Razqallah Hakem and Stephen E. Straus and Michael J Lenardo},
  year={2005}
}
Caspase-8, a proapoptotic protease, has an essential role in lymphocyte activation and protective immunity. We show that caspase-8 deficiency (CED) in humans and mice specifically abolishes activation of the transcription factor nuclear factor κB (NF-κB) after stimulation through antigen receptors, Fc receptors, or Toll-like receptor 4 in T, B, and natural killer cells. Caspase-8 also causes the αβ complex of the inhibitor of NF-κB kinase (IKK) to associate with the upstream Bcl10-MALT1 (mucosa… CONTINUE READING

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