Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.

@article{Nakayama1994RequirementFC,
  title={Requirement for CD8 beta chain in positive selection of CD8-lineage T cells.},
  author={Koh Nakayama and Izumi Negishi and Keisuke Kuida and Maggie C. Louie and Osami Kanagawa and Hiromitsu Nakauchi and Dennis Y. Loh},
  journal={Science},
  year={1994},
  volume={263 5150},
  pages={1131-3}
}
CD8 is either an alpha alpha homodimer or an alpha beta heterodimer, although most peripheral CD8-lineage T cells express only the CD8 alpha beta heterodimer. The physiological function of CD8 beta was elucidated with mice that were chimeric for the homozygous disruption of the CD8 beta gene. The CD8 beta-1- T cells developed normally to CD4+CD8+ stage, but did not efficiently differentiate further, which resulted in few peripheral CD8+ T cells. The number of peripheral CD8+ T cells was… CONTINUE READING

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