Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

@article{Shedlock2003RequirementFC,
  title={Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory},
  author={D. Shedlock and H. Shen},
  journal={Science},
  year={2003},
  volume={300},
  pages={337 - 339}
}
Although primary CD8 responses to acute infections are independent of CD4 help, it is unknown whether a similar situation applies to secondary responses. We show that depletion of CD4 cells during the recall response has minimal effect, whereas depletion during the priming phase leads to reduced responses by memory CD8 cells to reinfection. Memory CD8 cells generated in CD4+/+ mice responded normally when transferred into CD4−/− hosts, whereas memory CD8 cells generated in CD4−/− mice mounted… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
...
1
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...