Requirement for C5a in lung vascular injury following thermal trauma to rat skin.

@article{Schmid1997RequirementFC,
  title={Requirement for C5a in lung vascular injury following thermal trauma to rat skin.},
  author={Erik Schmid and Maria Teresa Piccolo and Hans Peter Friedl and Roscoe L. Warner and Michael S. Mulligan and Tony E. Hugli and Gerd O. Till and Peter A Ward},
  journal={Shock},
  year={1997},
  volume={8 2},
  pages={119-24}
}
Previous studies in rats have shown that deep second degree dermal burns, involving 28-30% of total body surface area, result in systemic complement activation, appearance in plasma of chemotactic activity, sequestration of blood neutrophils in lung capillaries, and development of neutrophil-dependent dermal vascular and lung vascular injury. Although blockade of complement activation or depletion of complement before skin burns has resulted in significant attenuation of tissue injury both… CONTINUE READING
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