Requirement for Abasic Endonuclease Gene Homologues in Arabidopsis Seed Development

@article{Murphy2009RequirementFA,
  title={Requirement for Abasic Endonuclease Gene Homologues in Arabidopsis Seed Development},
  author={Terence M. Murphy and Mark F Belmonte and Stephanie Shu and Anne B Britt and James Hatteroth},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={753 - 766}
}
Arabidopsis thaliana has three genes, Ape1L, Ape2, and Arp, that show homology to abasic (apurinic/apyrimidinic) endonuclease genes of bacterial, yeast, or animal cells. In bacteria, yeast, and animals, abasic endonucleases function in base excision repair of oxidized and other modified DNA bases. Here we report that plants with knock-out mutations in any one of Ape1L, Ape2, or Arp show no apparent differences from wild type in growth rate, growth habit, and fertility. However, coincident knock… CONTINUE READING

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