Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.

@article{Dyall2014RepurposingOC,
  title={Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.},
  author={Julie Dyall and Christopher M. Coleman and Brit J Hart and Thiagarajan Venkataraman and Michael R. Holbrook and Jason Kindrachuk and Reed F Johnson and Gene Garrard Olinger and Peter B Jahrling and Monique Laidlaw and Lisa Johansen and Calli M. Lear-Rooney and Pamela J. Glass and Lisa E. Hensley and Matthew B. Frieman},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 8},
  pages={4885-93}
}
Outbreaks of emerging infections present health professionals with the unique challenge of trying to select appropriate pharmacologic treatments in the clinic with little time available for drug testing and development. Typically, clinicians are left with general supportive care and often untested convalescent-phase plasma as available treatment options. Repurposing of approved pharmaceutical drugs for new indications presents an attractive alternative to clinicians, researchers, public health… CONTINUE READING
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