Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.

Abstract

A variety of human cancers, including nonsmall cell lung (NSCLC), breast, and colon cancers, are driven by the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. Having shown that bisphosphonates, a class of drugs used widely for the therapy of osteoporosis and metastatic bone disease, reduce cancer cell viability by targeting… (More)
DOI: 10.1073/pnas.1421422111

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