Repurposing celecoxib as a topical antimicrobial agent

  title={Repurposing celecoxib as a topical antimicrobial agent},
  author={Shankar Thangamani and Waleed Younis and Mohamed N Seleem},
  booktitle={Front. Microbiol.},
There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing approved drugs with known pharmacology and toxicology is an alternative strategy to accelerate antimicrobial research and development. In this study, we show that celecoxib, a marketed inhibitor of cyclooxygenase-2, exhibits broad-spectrum antimicrobial activity against Gram-positive pathogens from a variety of genera… CONTINUE READING
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