Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.

@article{Wiederhold2017RepurposingAA,
  title={Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi.},
  author={Nathan P Wiederhold and Thomas F. Patterson and Anand Srinivasan and Ashok Kumar Chaturvedi and Annette W. Fothergill and Floyd L Wormley and Anand Kumar Ramasubramanian and Jos{\'e} Luis L{\'o}pez-Ribot},
  journal={Virulence},
  year={2017},
  volume={8 2},
  pages={138-142}
}
Repositioning old drugs can significantly decrease the time and effort that it takes to develop novel antifungal therapeutics, which represents a pressing and unmet clinical need due to the devastating nature of fungal infections. We have previously described the activity of auranofin, a gold thiol compound used to treat rheumatoid arthritis, against Candida albicans biofilms. Here we evaluate its antifungal spectrum of action and describe its activity against a variety of medically important… CONTINUE READING
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