Repurposing Tecfidera for cancer

  title={Repurposing Tecfidera for cancer},
  author={L. Booth and M. Malkin and P. Dent},
  journal={Aging (Albany NY)},
  pages={1289 - 1290}
  • L. Booth, M. Malkin, P. Dent
  • Published 2016
  • Medicine
  • Aging (Albany NY)
  • The compound dimethyl fumarate (DMF) has been an approved drug in Europe for several decades as a therapeutic for psoriasis and relapsing-remitting multiple sclerosis (MS). More recently, the drug has been approved in The United States as an MS treatment (Tecfidera®). Upon ingestion, the drug is rapidly metabolized into the biologically active form of the agent, mono methyl fumarate (MMF); the biological actions of DMF and MMF in vitro are not identical, for example DMF modulates NFκB activity… CONTINUE READING
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