Repurposing Strategies for Therapeutics
@article{Sleigh2012RepurposingSF, title={Repurposing Strategies for Therapeutics}, author={S. Sleigh and C. L. Barton}, journal={Pharmaceutical Medicine}, year={2012}, volume={24}, pages={151-159} }
Drug repurposing refers to the development of existing drugs for new indications. These drugs may have (i) failed to show efficacy in late stage clinical trials, without safety issues; (ii) stalled in development for commercial reasons; (iii) passed the point of patent expiry; or (iv) are being explored in new geographical markets. Over the past 5 years, pressure on the industry caused by the ‘innovation gap’ of rising development costs and stagnant product output have become major reasons for… CONTINUE READING
104 Citations
Drug Repurposing: Considerations to Surpass While Re-directing Old Compounds for New Treatments.
- Business, Medicine
- Archives of medical research
- 2020
Drug reformulations and repositioning in the pharmaceutical industry and their impact on market access: regulatory implications
- Engineering, Medicine
- Journal of market access & health policy
- 2014
- 18
- Highly Influenced
Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak
- Medicine
- Viruses
- 2020
- 1
- PDF
Drug repurposing: a promising tool to accelerate the drug discovery process.
- Computer Science, Medicine
- Drug discovery today
- 2019
- 22
Drug reformulations and repositioning in pharmaceutical industry and its impact on market access: reassessment of nomenclature
- Engineering, Medicine
- Journal of market access & health policy
- 2013
- 31
Old wine in new bottles: Drug repurposing in oncology.
- Medicine
- European journal of pharmacology
- 2019
- 11
repositioning drugs and biologics: retargeting old/existing drugs for potential new therapeutic applications
- Medicine
- 2013
- 28
DRUG REPURPOSING: A STUDY OF THE POTENTIAL ANTITUMORGENIC ACTIVITY OF NONCHEMOTHERAPEUTIC DRUGS
- Medicine
- 2015
- 1
Drug repurposing and the prior art patents of competitors.
- Medicine, Biology
- Drug discovery today
- 2014
- 14
References
SHOWING 1-10 OF 11 REFERENCES
Lessons from 60 years of pharmaceutical innovation
- Medicine
- Nature Reviews Drug Discovery
- 2009
- 934
- Highly Influential
- PDF
Integration of indications discovery efforts at Pfizer
- International Drug Discovery 2010;
- 2010
Why big pharma needs to learn the three Rs [ editorial analysis ]
- Nat Rev Drug Discov
- 2009
Pharmaceutical product relaunch : preserving market share through line extension and new market entry strategies
- Drug repurposing
- 2007