Repurposing Strategies for Therapeutics
@article{Sleigh2012RepurposingSF, title={Repurposing Strategies for Therapeutics}, author={Sara H. Sleigh and Cheryl L. Barton}, journal={Pharmaceutical Medicine}, year={2012}, volume={24}, pages={151-159} }
Drug repurposing refers to the development of existing drugs for new indications. These drugs may have (i) failed to show efficacy in late stage clinical trials, without safety issues; (ii) stalled in development for commercial reasons; (iii) passed the point of patent expiry; or (iv) are being explored in new geographical markets. Over the past 5 years, pressure on the industry caused by the ‘innovation gap’ of rising development costs and stagnant product output have become major reasons for…
125 Citations
Drug Repurposing: Considerations to Surpass While Re-directing Old Compounds for New Treatments.
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Drug Repurposing: Far Beyond New Targets for Old Drugs
- BiologyThe AAPS Journal
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This approach is of interest primarily because the authors continue to face significant gaps in the drug–target interactions matrix and to accumulate safety and efficacy data during clinical studies.
Drug reformulations and repositioning in the pharmaceutical industry and their impact on market access: regulatory implications
- MedicineJournal of market access & health policy
- 2014
Evaluating the regulatory path associated with each type of repurposing strategy according to the previously proposed nomenclature confirmed that repositioning strategies were usually filed under a more complex regulatory process than reformulations.
Drug repurposing for SARS-CoV-2 (COVID-19) treatment
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Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak
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The past success in drug repositioning, the current technological advancement in the field, drug Repositioning for personalised medicine and the ongoing research on newly emerging drugs under consideration for the COVID-19 treatment are discussed.
Drug repositioning: Progress and challenges in drug discovery for various diseases
- Biology, MedicineEuropean Journal of Medicinal Chemistry
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Drug repurposing: a promising tool to accelerate the drug discovery process.
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- 2019
Drug reformulations and repositioning in pharmaceutical industry and its impact on market access: reassessment of nomenclature
- MedicineJournal of market access & health policy
- 2013
A harmonized nomenclature for drug repositioning, reformulation, and combination cases will allow for a robust analysis of the added value and market access conditions attributed for each strategy and case type as assessed by regulators and payors in Europe and the United States.
Old wine in new bottles: Drug repurposing in oncology.
- Biology, MedicineEuropean journal of pharmacology
- 2019
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