Repurposing Strategies for Therapeutics

@article{Sleigh2012RepurposingSF,
  title={Repurposing Strategies for Therapeutics},
  author={Sara H. Sleigh and Cheryl L. Barton},
  journal={Pharmaceutical Medicine},
  year={2012},
  volume={24},
  pages={151-159}
}
Drug repurposing refers to the development of existing drugs for new indications. These drugs may have (i) failed to show efficacy in late stage clinical trials, without safety issues; (ii) stalled in development for commercial reasons; (iii) passed the point of patent expiry; or (iv) are being explored in new geographical markets. Over the past 5 years, pressure on the industry caused by the ‘innovation gap’ of rising development costs and stagnant product output have become major reasons for… Expand
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Drug Repurposing: Considerations to Surpass While Re-directing Old Compounds for New Treatments.
TLDR
The most important concerns that affect the pathway of drug repurposing are discussed, with special emphasis on the economic revenues, government-industry associations, and legal considerations that together impact the pharmaceutical industry's decision-making on which compounds may be eligible for repurpose. Expand
Drug Repurposing: Far Beyond New Targets for Old Drugs
TLDR
This approach is of interest primarily because the authors continue to face significant gaps in the drug–target interactions matrix and to accumulate safety and efficacy data during clinical studies. Expand
Drug reformulations and repositioning in the pharmaceutical industry and their impact on market access: regulatory implications
TLDR
Evaluating the regulatory path associated with each type of repurposing strategy according to the previously proposed nomenclature confirmed that repositioning strategies were usually filed under a more complex regulatory process than reformulations. Expand
Repurposing old molecules for new indications: Defining pillars of success from lessons in the past.
TLDR
Through a meticulous examination of some failed repurposing attempts, this review aimed to identify key factors leading to high attrition rate in such studies and defined four pillars toward improving success rate. Expand
Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak
TLDR
The past success in drug repositioning, the current technological advancement in the field, drug Repositioning for personalised medicine and the ongoing research on newly emerging drugs under consideration for the COVID-19 treatment are discussed. Expand
Drug repurposing: a promising tool to accelerate the drug discovery process.
TLDR
Drug repurposing has gained importance in identifying new therapeutic uses for already-available drugs and it provides a novel way to explore old drugs for new use but encounters several challenges. Expand
Drug reformulations and repositioning in pharmaceutical industry and its impact on market access: reassessment of nomenclature
TLDR
A harmonized nomenclature for drug repositioning, reformulation, and combination cases will allow for a robust analysis of the added value and market access conditions attributed for each strategy and case type as assessed by regulators and payors in Europe and the United States. Expand
Old wine in new bottles: Drug repurposing in oncology.
TLDR
A number of promising candidates, such as aspirin, artesunate, cimetidine, doxycycline, ivermectin, metformin, rapamycin, and thalidomide, that have the potential to be repurposed as anticancer drugs both in cancer prevention and therapy are provided. Expand
repositioning drugs and biologics: retargeting old/existing drugs for potential new therapeutic applications
TLDR
Experts are of the opinion that repositioning drug technology will have better integration in Pharma research for the next decade as several phases common to de novo drug discovery and development can be bypassed as compared with traditional discovery. Expand
DRUG REPURPOSING: A STUDY OF THE POTENTIAL ANTITUMORGENIC ACTIVITY OF NONCHEMOTHERAPEUTIC DRUGS
TLDR
The top 12 drugs and what they were originally intended for, and how they might be useful in cancer treatment are outlined, and growth curves and colonogenic assays were performed using these drugs as an example of how drug repurposing might be studied in a laboratory setting. Expand
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