Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System

@inproceedings{May2018RepurposingAE,
  title={Repurposing Auranofin, Ebselen, and PX-12 as Antimicrobial Agents Targeting the Thioredoxin System},
  author={Holly C. May and Jieh-Juen Yu and M. Neal Guentzel and James P. Chambers and Andrew P Cap and Bernard. P. Arulanandam},
  booktitle={Front. Microbiol.},
  year={2018}
}
As microbial resistance to drugs continues to rise at an alarming rate, finding new ways to combat pathogens is an issue of utmost importance. Development of novel and specific antimicrobial drugs is a time-consuming and expensive process. However, the re-purposing of previously tested and/or approved drugs could be a feasible way to circumvent this long and costly process. In this review, we evaluate the U.S. Food and Drug Administration tested drugs auranofin, ebselen, and PX-12 as… CONTINUE READING