Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling

@article{Li2012RepulsiveGM,
  title={Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling},
  author={Jin Li and Lin Ye and Andrew James Sanders and Wen Guo Jiang},
  journal={Journal of Cellular Biochemistry},
  year={2012},
  volume={113}
}
Repulsive guidance molecules (RGMs) coordinate axon formation and iron homestasis. These molecules are also known as co‐receptors of bone morphogenetic proteins (BMPs). However, the role played by RGMs in breast cancer remains unclear. The present study investigated the impact of RGMB on functions of breast cancer cells and corresponding mechanisms. RGMB was knocked down in breast cancer cells by way of an anti‐RGMB ribozyme transgene. Knockdown of RGMB resulted in enhanced capacities of… 
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