Repulsive Guidance Molecule-a and Demyelination: Implications for Multiple Sclerosis

  title={Repulsive Guidance Molecule-a and Demyelination: Implications for Multiple Sclerosis},
  author={Takekazu Kubo and Shigeru Tokita and Toshihide Yamashita},
  journal={Journal of Neuroimmune Pharmacology},
Drug development for neurodegenerative and neuroinflammatory diseases such as multiple sclerosis and traumatic brain injury is challenging. One promising strategy is to target a molecule with multiple biological actions affecting divergent pathophysiological disease phases simultaneously since these diseases arise from multiple pathological phases. In recent years, we pursued this strategy with a focus on multiple sclerosis and spinal cord injury and found that repulsive guidance molecule-a… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 36 references

Multiple sclerosis.

The New England journal of medicine • 2000
View 4 Excerpts
Highly Influenced

Autoimmune disease: New drug target for MS?

Nature Reviews Drug Discovery • 2011
View 2 Excerpts

Disease Modifying Agents for Multiple Sclerosis

The open neurology journal • 2010
View 2 Excerpts

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