Repulsion and Attraction of Axons by Semaphorin3D Are Mediated by Different Neuropilins In Vivo

@article{Wolman2004RepulsionAA,
  title={Repulsion and Attraction of Axons by Semaphorin3D Are Mediated by Different Neuropilins In Vivo},
  author={M. Wolman and Y. Liu and Hiroshi Tawarayama and W. Shoji and M. Halloran},
  journal={The Journal of Neuroscience},
  year={2004},
  volume={24},
  pages={8428 - 8435}
}
Class 3 semaphorins are known to repel and/or sometimes attract axons; however, their role in guiding developing axons in the CNS in vivo is still essentially unknown. We investigated the role of Semaphorin3D (Sema3D) in the formation of the early axon pathways in the zebrafish CNS. Morpholino knock-down shows that Sema3D is essential for the correct formation of two early axon pathways. Sema3D appears to guide axons of the nucleus of the medial longitudinal fasciculus (nucMLF) by repulsion and… Expand
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  • R. Fiore, A. Püschel
  • Medicine, Biology
  • Frontiers in bioscience : a journal and virtual library
  • 2003
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