Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing

  title={Reprogramming the Dynamin 2 mRNA by Spliceosome-mediated RNA Trans-splicing},
  author={Delphine Trochet and Bernard Prudhon and Arnaud Jollet and Stéphanie Lorain and Marc Bitoun},
  journal={Molecular Therapy. Nucleic Acids},
Dynamin 2 (DNM2) is a large GTPase, ubiquitously expressed, involved in membrane trafficking and regulation of actin and microtubule cytoskeletons. DNM2 mutations cause autosomal dominant centronuclear myopathy which is a rare congenital myopathy characterized by skeletal muscle weakness and histopathological features including nuclear centralization in absence of regeneration. No curative treatment is currently available for the DNM2-related autosomal dominant centronuclear myopathy. In order… 

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